1882-72-0

Basic information

• Product Name: methyl 2-amino-5-hydroxybenzoate
• Synonyms: 2-AMino-5-hydroxy-benzoic acid Methyl ester;4-hydroxy-2-(Methoxycarbonyl)benzenaMine;Methyl 5-Hydroxyanthranilate;methyl 2-amino-5-hydroxybenzoate
• CAS NO: 1882-72-0
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.163
• Mol File: 1882-72-0.mol
• Article Data: 26

Chemical Properties

• Melting Point: 158.0 to 162.0 °C
• Boiling Point: 357.4 °C at 760 mmHg
• Flash Point: 170 °C
• Appearance: /
• Density: 1.305 g/cm³
• Vapor Pressure: 1.33E-05mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: slightly sol. in Methanol
• PKA: 9.41±0.18(Predicted)
• CAS DataBase Reference: methyl 2-amino-5-hydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-amino-5-hydroxybenzoate(1882-72-0)
• EPA Substance Registry System: methyl 2-amino-5-hydroxybenzoate(1882-72-0)

Safety Data

• Hazardous Substances Data: 1882-72-0(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-5-hydroxybenzoate is a chemical compound with the molecular formula C8H9NO3. It is also known as methyl anthranilate and is commonly used as a fragrance and flavoring agent in various consumer products such as perfumes, soaps, and cosmetics. It has a sweet, fruity odor and is often found in natural products such as jasmine and orange flower. Methyl 2-amino-5-hydroxybenzoate is also used in the synthesis of pharmaceuticals and as an intermediate in organic chemical reactions. Additionally, it has been studied for its potential antioxidant and antimicrobial properties.

InChI:InChI=1/C8H9NO3/c1-12-8(11)6-4-5(10)2-3-7(6)9/h2-4,10H,9H2,1H3

Upstream product

• 67-56-1 methanol 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 606-27-9 methyl 2-nitrobenzoate 
• 78164-38-2 Avenalumin 1 
• 78183-21-8 avenalumin I diacetate 
• 186581-53-3 diazomethane 
• 1882-75-3 6-acetoxy-2-methyl-4H-3,1-benzoxazin-4-one 
• 59216-77-2 methyl 5-hydroxy-2-nitro-benzoate 

Downstream Products

• 622411-10-3 methyl 2-amino-5{{(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}methoxy}benzoate 
• 409093-33-0 N-[4-(tert-butyl-dimethyl-silanyloxy)-2-formyl-phenyl]-4-methyl-benzenesulfonamide 
• 409093-32-9 5-(tert-butyl-dimethyl-silanyloxy)-2-(toluene-4-sulfonylamino)-benzoic acid methyl ester 
• 409093-35-2 5-[5-(tert-butyldimethylsiloxy)-2-(4-methylbenzenesulfonylamino)phenyl]-5-hydroxypent-2-enoic acid methyl ester 
• 791810-63-4 N-[4-benzyloxy-2-(1-hydroxybut-3-enyl)phenyl]-4-methylbenzenesulfonamide 
• 791810-76-9 N-[4-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-but-3-enyl)-phenyl]-4-methyl-benzenesulfonamide 
• 791810-67-8 N-[4-benzyloxy-2-(1,5-dihydroxy-pent-3-enyl)-phenyl]-4-methyl-benzenesulfonamide 
• 791810-79-2 (Z)-1,5-diacetoxy-5-[5-benzyloxy-2-(4-methylbenzenesulfonylamino)phenyl]-2-pentene 
• 791810-77-0 N-{4-(tert-butyl-dimethyl-silanyloxy)-2-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-enyl]-phenyl}-4-methyl-benzenesulfonamide 
• 791810-64-5 N-[4-benzyloxy-2-(1-(allyloxydiphenylsilyloxy)but-3-enyl)phenyl]-4-methylbenzenesulfonamide 
• 1067910-13-7 C₁₄H₁₂INO₅S 

Relevant articles and documents

Polyvalent Catalysts Operating on Polyvalent Substrates: A Model for Surface-Controlled Reactivity

Unusually fast rates of nucleophilic catalysis of hydrazone ligation were observed when polyvalent anthranilic acid catalysts operating on polyvalent aldehyde substrates were used with PAMAM dendrimers as the common platform. When presented in this way, t

Distinct urinary metabolite profiles of two pharmacologically active N-methylanthranilates: Three approaches to xenobiotic metabolite identification

Two volatile alkaloids, isopropyl N-methylanthranilate (IMA) and methyl N-methylanthranilate (MMA), present in the human diet and cosmetic products, were recently demonstrated to possess important pharmacological activities. While MMA is considered to be phototoxic, there is scarce data on the toxicity of IMA. Herein, we analyzed urinary metabolites of IMA and MMA in rats (200 mg kg?1, i.p., 7 days) by combining three different approaches: 1) preparative chromatography, 2) synthesis, and 3) SPR. The preparative approach, Sephadex LH-20 chromatography of the extract of urine samples of IMA treated animals, in conjunction with NMR, enabled the identification of 16 different anthranilate derivatives, among which products of aromatic core hydroxylation (isopropyl 5-hydroxy-N-methylanthranilate, isopropyl 5-hydroxyantranilate, isopropyl 3-hydroxyantranilate) were the major ones. The first application of the synthetic/combinatorial approach led to a successful identification of MMA metabolites, where 2-(methylamino)benzamide and N-methylanthranilic acid were the principal ones, among 14 others. Generally, MMA and IMA undergo analogous biotransformation pathways; however, MMA predominantly underwent chemical conversions of the ester group, i.e. transformation into derivatives of anthranilamide and anthranilic acid, while the major metabolic pathway of IMA was hydroxylation of the aromatic core. Additionally, pathohistological examinations revealed no signs of liver toxicity, or other signs of toxicity.

Compounds for use in inhibiting HIV capsid assembly

The present invention relates to a compound or a pharmaceutically acceptable salt or solvate thereof for use in inhibiting HIV capsid assembly, the compound comprising the core structure wherein E is CR7or S, and wherein f is 0 or 1, and wherein in case E is S, f is 0, and wherein the core structure is at least substituted in 2 and 4 position, and wherein the residue R6 and R7, are, independently of each other, selected from the group consisting of -H, -D, -alkyl, alkoxy, alkenyl, alkynyl, halides, -NO2, - OH, - NH2, -NHR4#, -CN, -S(O)R4#, -SO2R4#, -P(O)R4#R5#, -P(O)(OR4#)R5#, - P(O)(OR4#)(OR5#), -C(O)NR4#R5#, -C(O)SR4#, -C(O)R4#, -C(O)O-R4#, alkoxy and glycol chains; and wherein R6 may optionally form a cyclic residue, with a further substituent present 5 or 6 position, and wherein R4# and R5# are, independently of each other, selected from the group consisting of -H, -alkyl, -alkenyl, - heterocycloalkyl, aryl and heteroaryl.