3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester

Base Information

Chemical Name:3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester
CAS No.:1026013-99-9
Molecular Formula:C₁₆H₁₃ClFNO₃
Molecular Weight:321.736
Hs Code.:

Synonyms:3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester

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Chemical Property of 3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester

There total 1 articles about 3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 587-88-2
ethyl 2-(4-fluorophenyl)acetate

: 1026013-99-9
3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester

Guidance literature:: ethyl 2-(4-fluorophenyl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

6-Chloronicotinoyl chloride; In tetrahydrofuran; for 1h;
DOI:10.1021/jm030327l

Reference yield:

: 1026013-99-9
3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester

: 214831-66-0
1-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-ethanone

Guidance literature:: With water; In dimethyl sulfoxide; at 150 ℃; for 3h;
DOI:10.1021/jm030327l

Reference yield:

: 1026013-99-9
3-(6-chloro-pyridin-3-yl)-2-(4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester

: 214831-67-1
2-(4-fluoro-phenyl)-1-(6-morpholin-4-yl-pyridin-3-yl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O / dimethylsulfoxide / 3 h / 150 °C

2: ethanol / 18 h / Heating

With water; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm030327l