ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate

Base Information

Chemical Name:ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate
CAS No.:483337-62-8
Molecular Formula:C₁₇H₂₄N₂O₄
Molecular Weight:320.389
Hs Code.:

Synonyms:ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate

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Technology Process of ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate

There total 5 articles about ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5804-85-3
diethylaluminium cyanide

: 409092-97-3
(2S,3S)-ethyl 3-formyl-2-[(4-methoxyphenyl)amino]-4-methylpentanoate

: 483337-62-8
ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate

Guidance literature:: In tetrahydrofuran; toluene; at -75 ℃; for 2.5h;
DOI:10.1002/chem.200305646

Reference yield:

: 124156-21-4
ethyl (4-methoxyphenylimino)acetate

: 483337-62-8
ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: L-proline / tetrahydrofuran / 20 °C

2: tetrahydrofuran; toluene / 3 h / -78 °C

With L-proline; In tetrahydrofuran; toluene;
DOI:10.1021/ol027048x

Reference yield:

: 590-86-3
isovaleraldehyde

: 483337-62-8
ethyl (2S,3S)-3-[(R)-cyanohydroxymethyl]-2-(p-methoxyphenylamino)-4-methyl-pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: L-proline / tetrahydrofuran / 20 °C

2: tetrahydrofuran; toluene / 3 h / -78 °C

With L-proline; In tetrahydrofuran; toluene;
DOI:10.1021/ol027048x