409092-97-3Relevant articles and documents
A way to highly enantiomerically enriched aza-Morita-Baylis-Hillman-type products
Utsumi, Naoto,Zhang, Haile,Tanaka, Fujie,Barbas III, Carlos F.
, p. 1878 - 1880 (2007)
(Chemical Equation Presented) Going Mannich: Difficult to synthesize β-amino carbonyl compounds bearing α-alkylidene groups have been prepared enantioselectively (up to 99% ee) by reaction of β-substituted α,β-unsaturated aldehydes and α-imino esters in t
Direct organocatalytic asymmetric Mannich-type reactions in aqueous media: One-pot Mannich-allylation reactions
Córdova, Armando,Barbas III, Carlos F.
, p. 1923 - 1926 (2003)
The first direct organocatalytic asymmetric Mannich-type reactions in aqueous media are demonstrated herein. L-Proline-catalyzed reactions in aqueous media to provide β-formyl substituted α-amino acid derivatives with excellent diastereoselectivities (dr
Diastereoselective Hydrolysis of Branched Malonate Diesters by Porcine Liver Esterase: Synthesis of 5-Benzyl-Substituted Cα-Methyl-β-proline and Catalytic Evaluation
Kotapati, Hari Kiran,Robinson, Jamarii D.,Lawrence, Daniel R.,Fortner, Kimberly R.,Stanford, Caleb W.,Powell, Douglas R.,Wardenga, Rainer,Bornscheuer, Uwe T.,Masterson, Douglas S.
, p. 3009 - 3016 (2017/06/06)
Malonate diesters with highly branched side chains containing a preexisting chiral center were prepared from optically pure amino alcohols and subjected to asymmetric enzymatic hydrolysis by Porcine Liver Esterase (PLE). Recombinant PLE isoenzymes have be
Indoline-3-carboxylic acid derived organocatalysts for the anti-mannich reaction
Pietruszka, Joerg,Simon, Robert Christian
, p. 14534 - 14544 (2011/03/20)
Mannich type reactions of a preformed aldimine with various carbonyl compounds were investigated with a series of functionalised indoline derivatives as catalysts: indoline-3-carboxylic acid, the diphenylcarbinol analogue and O-protected silyl ether analo