3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole

Base Information

Chemical Name:3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole
CAS No.:1263483-60-8
Molecular Formula:C₂₃H₂₁BrFN₃O₃
Molecular Weight:486.34
Hs Code.:

Synonyms:3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole

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Chemical Property of 3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole

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Technology Process of 3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole

There total 9 articles about 3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263483-59-5
2-(4-Bromo-3-fluorophenyl)-2-oxoethyl 2-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]butanoate

: 1263483-60-8
3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole

Guidance literature:: With 2,2,2-trifluoroacetic acid ammonia; at 150 ℃; for 6h;

Reference yield:

: 153556-42-4
4-bromo-3-fluorobenzoic acid

: 1263483-60-8
3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: hydrogen bromide; acetic acid / dichloromethane / 0.17 h / Cooling with ice

3.1: triethylamine / acetone / 2 h / 20 °C

4.1: 2,2,2-trifluoroacetic acid ammonia / 6 h / 150 °C

With oxalyl dichloride; hydrogen bromide; 2,2,2-trifluoroacetic acid ammonia; acetic acid; triethylamine; N,N-dimethyl-formamide; In dichloromethane; acetone;

Reference yield:

: 1263320-49-5
ethyl 2-{4-[amino(hydroxyimino)methyl]phenoxy}butanoate

: 1263483-60-8
3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / water / 2 h / 100 °C

2: sodium hydroxide; water / tetrahydrofuran; methnolanol / 0.5 h / 20 °C

3: triethylamine / acetone / 2 h / 20 °C

4: 2,2,2-trifluoroacetic acid ammonia / 6 h / 150 °C

With pyridine; water; 2,2,2-trifluoroacetic acid ammonia; triethylamine; sodium hydroxide; In tetrahydrofuran; methnolanol; water; acetone;