Technology Process of 2-Fluoro-4-(2-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,3-oxazol-4-yl)benzoic acid
There total 10 articles about 2-Fluoro-4-(2-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,3-oxazol-4-yl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
carbon monoxide; 3-(4-{1-[4-(4-Bromo-3-fluorophenyl)-1,3-oxazol-2-yl]propoxy}phenyl)-5-isopropyl-1,2,4-oxadiazole;
With
triethylamine;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
methanol; N,N-dimethyl-formamide;
at 20 ℃;
for 5h;
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C
1.2: 0.5 h / 20 °C
2.1: hydrogen bromide; acetic acid / dichloromethane / 0.17 h / Cooling with ice
3.1: triethylamine / acetone / 2 h / 20 °C
4.1: 2,2,2-trifluoroacetic acid ammonia / 6 h / 150 °C
5.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide; methanol / 5 h / 20 °C
5.2: 2.5 h / 20 °C
With
oxalyl dichloride; hydrogen bromide; 2,2,2-trifluoroacetic acid ammonia; acetic acid; triethylamine;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; N,N-dimethyl-formamide;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetonitrile / 3 h / 80 °C
2.1: hydroxylamine / ethanol; water / 2.5 h / 80 °C
3.1: pyridine / water / 2 h / 100 °C
4.1: sodium hydroxide; water / tetrahydrofuran; methnolanol / 0.5 h / 20 °C
5.1: triethylamine / acetone / 2 h / 20 °C
6.1: 2,2,2-trifluoroacetic acid ammonia / 6 h / 150 °C
7.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide; methanol / 5 h / 20 °C
7.2: 2.5 h / 20 °C
With
pyridine; water; hydroxylamine; 2,2,2-trifluoroacetic acid ammonia; potassium carbonate; triethylamine; sodium hydroxide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; methanol; ethanol; methnolanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;
