ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85

Base Information

• Chemical Name: ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85
• CAS No.: 40175-06-2
• Molecular Formula: C9H15NO2
• Molecular Weight: 169.224
• Hs Code.: 2933399090
• Mol file: 40175-06-2.mol

Synonyms:ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85;ethyl 1-methyl-1,2,3,6-tetrahydro-4-pyridinecarbo;ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85%;1-Methyl-1,2,3,6-tetrahydro-4-pyridinecarboxylic acid ethyl ester;

Chemical Property of ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85

Chemical Property:

• Vapor Pressure: 0.0676mmHg at 25°C
• Refractive Index: n20/D 1.478(lit.)
• Boiling Point: 108-109.5 °C/15 mmHg(lit.)
• Flash Point: 101 °C
• PSA: 29.54000
• Density: 1.025 g/mL at 25 °C(lit.)
• LogP: 0.74930
• Storage Temp.: 2-8°C

Purity/Quality:

98% or more ^*data from raw suppliers

ethyl1-methyl-1,2,3,6-tetrahydropyridine-4-carboxylate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85

There total 3 articles about ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

isonicotinic acid ethylester (1570-45-2) + methyl iodide (74-88-4) → ethyl 1-methyl-1,2,5,6-tetrahydropyridine-4-carboxylate (40175-06-2)

Guidance literature:

isonicotinic acid ethylester; methyl iodide; In ethyl acetate; at 80 ℃; for 3h;

With sodium tetrahydroborate; In ethanol; at -40 - 20 ℃; for 2h;

Reference yield:

1-methyl-4-ethoxycarbonylpyridinium iodide (10129-59-6) → ethyl 1-methyl-1,2,5,6-tetrahydropyridine-4-carboxylate (40175-06-2)

Guidance literature:

With sodium tetrahydroborate; ethanol; unter Kuehlung;

Reference yield:

→ ethyl 1-methyl-1,2,5,6-tetrahydropyridine-4-carboxylate (40175-06-2)

Guidance literature:

1-Methyl-4-ethoxycarbonyl-pyridiniumiodid, Me., NaBH4;

upstream raw materials:

1-methyl-4-ethoxycarbonylpyridinium iodide

isonicotinic acid ethylester

methyl iodide

Downstream raw materials:

1-benzyl-4-ethoxycarbonyl-1,2,3,6-tetrahydro-1-methylpyridinium bromide

(1S,3S,4R)-3-(4-Chloro-phenylsulfanyl)-1-methyl-piperidine-4-carboxylic acid ethyl ester

ethyl 1-methylisonipecotate

Refernces

• 1、 Proctor, George R.,Smith, Francis J.. "Bridged-ring Nitrogen Compounds. Part 5. Synthesis of 2,6-Methano-3-benzazonine ring-system". . p. 1754 - 1762. Retrieved 2007/10/02.