(3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride

Base Information

Chemical Name:(3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride
CAS No.:1076230-21-1
Molecular Formula:C₂₃H₂₃F₇N₂O*ClH
Molecular Weight:512.898
Hs Code.:

Synonyms:(3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride

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Chemical Property of (3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride

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Technology Process of (3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride

There total 9 articles about (3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl (3S,4S)-4-([3,5-bis(trifluoromethyl)benzyl](methyl)carbamoyl)-3-(4-fluoro-2-methylphenyl)piperidine-1-carboxylate

: 1076230-21-1
(3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 20 ℃;
DOI:10.1016/j.bmc.2011.11.048

Reference yield:

: 40175-06-2
ethyl 1-methyl-1,2,5,6-tetrahydropyridine-4-carboxylate

: 1076230-21-1
(3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide / diethyl ether / -10 - 0 °C

1.2: -50 - 10 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 1 h / Reflux

2.2: 2 h / 80 °C

2.3: 14 h / 20 °C

3.1: sodium methylate / methanol / 3 h / Reflux

3.2: 3 h / 50 °C

4.1: acetone / 2 h / 20 °C

5.1: citric acid / water; ethyl acetate / 1 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 3 h / 20 °C

7.1: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; copper(l) iodide; carbonochloridic acid 1-chloro-ethyl ester; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; citric acid; In methanol; diethyl ether; water; ethyl acetate; 1,2-dichloro-ethane; acetone; acetonitrile;
DOI:10.1016/j.bmc.2011.11.048

Reference yield:

: 1357586-70-9
(3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

: 1076230-21-1
(3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: citric acid / water; ethyl acetate / 1 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 3 h / 20 °C

3: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; citric acid; In water; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2011.11.048