[2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

Base Information

Chemical Name:[2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester
CAS No.:1000049-67-1
Molecular Formula:C₁₅H₂₂ClFN₂O₂
Molecular Weight:316.803
Hs Code.:

Synonyms:[2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

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Chemical Property of [2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

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Technology Process of [2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

There total 1 articles about [2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 452-83-5
2-chloro-5-fluoroaniline

: 109608-77-7
2-tert-butoxycarbonylamino-2-methylpropanal

: 1000049-67-1
[2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

Guidance literature:: 2-chloro-5-fluoroaniline; 2-tert-butoxycarbonylamino-2-methylpropanal; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 0 - 20 ℃; for 16h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield: 80.0%

: 1000049-67-1
[2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

: 598-21-0
2-Bromoacetyl bromide

: 1000049-71-7
{2-[(2-bromoacetyl)-(2-chloro-5-fluorophenyl)amino]-1,1-dimethylethyl}carbamic acid t-butyl ester

Guidance literature:: In N,N-dimethyl acetamide; at 0 ℃; for 0.25h;

Reference yield:

: 1000049-67-1
[2-(2-chloro-5-fluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

: 1000047-67-5
1-(2-chloro-5-fluorophenyl)-5,5-dimethylpiperazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl acetamide / 0 °C

2: potassium tert-butylate / tetrahydrofuran / 0 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With potassium tert-butylate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2012.05.092