tert-butyl 2-formylpropan-2-ylcarbamate

Base Information

• Chemical Name: tert-butyl 2-formylpropan-2-ylcarbamate
• CAS No.: 109608-77-7
• Molecular Formula: C9H17 N O3
• Molecular Weight: 187.239
• Hs Code.: 2924199090
• Mol file: 109608-77-7.mol

Synonyms:Carbamicacid, (1,1-dimethyl-2-oxoethyl)-, 1,1-dimethylethyl ester (9CI);(1,1-Dimethyl-2-oxoethyl)carbamic acid tert-butyl ester

Chemical Property of tert-butyl 2-formylpropan-2-ylcarbamate

Chemical Property:

• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.44
• Boiling Point: 260.345°C at 760 mmHg
• PKA: 10.88±0.46(Predicted)
• Flash Point: 111.253°C
• PSA: 55.40000
• Density: 1.002g/cm³
• LogP: 1.87950
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl(2-Methyl-1-oxopropan-2-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 2-formylpropan-2-ylcarbamate

There total 8 articles about tert-butyl 2-formylpropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-((tert-butyloxycarbonyl)amino)-2-methylpropan-1-ol (102520-97-8) → 2-tert-butoxycarbonylamino-2-methylpropanal (109608-77-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield: 96.0%

→ 2-tert-butoxycarbonylamino-2-methylpropanal (109608-77-7)

Guidance literature:

Reference yield: 68.0%

<2-(methoxymethylamino)-1,1-dimethyl-2-oxoethyl>carbamic acid, 1,1,-dimethylethyl ester (160816-27-3) → 2-tert-butoxycarbonylamino-2-methylpropanal (109608-77-7)

Guidance literature:

<2-(methoxymethylamino)-1,1-dimethyl-2-oxoethyl>carbamic acid, 1,1,-dimethylethyl ester; With lithium triethylborohydride; In tetrahydrofuran; at -40 - 20 ℃; for 1.5h;

With citric acid; In tetrahydrofuran; water;

upstream raw materials:

2-((tert-butyloxycarbonyl)amino)-2-methylpropan-1-ol

di-tert-butyl dicarbonate

<2-(methoxymethylamino)-1,1-dimethyl-2-oxoethyl>carbamic acid, 1,1,-dimethylethyl ester

oxalyl dichloride

Downstream raw materials:

[1,1-dimethyl-2-(2-methylphenylamino)ethyl]carbamic acid t-butyl ester

[2-(2,6-difluorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

[2-(2-chlorophenylamino)-1,1-dimethylethyl]carbamic acid t-butyl ester

[1,1-dimethyl-2-(5-fluoro-2-methylphenylamino)ethyl]carbamic acid t-butyl ester

Refernces

• 1、 -. "NOVEL POTASSIUM CHANNEL INHIBITORS". Page/Page column 56. . Retrieved 2020/10/20.
• 2、 -. "NOVEL TRITERPENE DERIVATIVES AS HIV INHIBITORS". Page/Page column 29-30. . Retrieved 2020/08/28.