(E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

Base Information

Chemical Name:(E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate
CAS No.:331687-62-8
Molecular Formula:C₁₈H₂₇NO₄Si
Molecular Weight:349.502
Hs Code.:

Synonyms:(E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

Suppliers and Price of (E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

Chemical Property:

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Technology Process of (E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

There total 3 articles about (E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 4530-20-5
BOC-glycine

: 101844-21-7
(E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-ol

: 331687-62-8
(E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1002/hlca.200290002

Reference yield:

: 43019-63-2
3-(phenyldimethylsilyl)prop-2-yn-1-ol

: 331687-62-8
(E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / sodium bis(2-methoxyethoxy)aluminum hydride / ethanol / 0.5 h / 5 °C

2: 81 percent / DMAP; DCC / CH₂Cl₂

With dmap; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; In ethanol; dichloromethane;
DOI:10.1002/hlca.200290002

Reference yield:

: 768-33-2
phenyldimethylsilyl chloride

: 331687-62-8
(E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: EtMgBr / tetrahydrofuran

1.2: 70 percent / tetrahydrofuran / 2 h / Heating

2.1: 65 percent / sodium bis(2-methoxyethoxy)aluminum hydride / ethanol / 0.5 h / 5 °C

3.1: 81 percent / DMAP; DCC / CH₂Cl₂

With dmap; ethylmagnesium bromide; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/hlca.200290002