4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

Base Information

Chemical Name:4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine
CAS No.:118043-68-8
Molecular Formula:C₁₈H₁₉N₅O₃
Molecular Weight:353.381
Hs Code.:

Synonyms:4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

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Chemical Property of 4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

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Technology Process of 4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

There total 4 articles about 4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 118043-67-7
2-amino-5-cyano-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

: 118043-69-9
2-amino-5-cyano-7-<(1,3-dihydroxy-2-propoxy)methyl>pyrrolo<2,3-d>pyrimidine

: 118043-68-8
4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

: 1500-90-9
4-amino-5-cyanopyrrolo<2,3-d>pyrimidine

Guidance literature:: With boron trichloride; In dichloromethane; a) - 78 deg C, 2 h, b) -60 deg C, 4 h;
DOI:10.1021/jm00122a019

Reference yield:

: 19393-83-0
4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine

: 118043-68-8
4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium hydride / 1.) DMF, 80 deg C, 0.5 h, 2.) DMF, 80 deg C, 5 h

2: 48 percent / hydrogen / 5percent Pd/C, MgO / ethyl acetate / 6 h / 2482.3 Torr

3: 7 percent / boron trichloride / CH₂Cl₂ / a) - 78 deg C, 2 h, b) -60 deg C, 4 h

With hydrogen; boron trichloride; sodium hydride; palladium on activated charcoal; magnesium oxide; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00122a019

Reference yield:

: 74564-16-2
1,3-dibenzyloxy-2-(chloromethoxy)propane

: 118043-68-8
4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium hydride / 1.) DMF, 80 deg C, 0.5 h, 2.) DMF, 80 deg C, 5 h

2: 48 percent / hydrogen / 5percent Pd/C, MgO / ethyl acetate / 6 h / 2482.3 Torr

3: 7 percent / boron trichloride / CH₂Cl₂ / a) - 78 deg C, 2 h, b) -60 deg C, 4 h

With hydrogen; boron trichloride; sodium hydride; palladium on activated charcoal; magnesium oxide; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00122a019