ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

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Chemical Name:ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate
CAS No.:1356600-28-6
Molecular Formula:C₂₇H₂₈FNO₅
Molecular Weight:465.521
Hs Code.:

Synonyms:ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

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Chemical Property of ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

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Technology Process of ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

There total 5 articles about ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.02%

: 691904-78-6
3-(2-fluoro-4-hydroxyphenyl)propanoic acid ethyl ester

: 1356599-86-4
(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol

: 1356600-28-6
ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1269763-69-0
ethyl (2E,2Z)-3-(2-fluoro-4-methoxyphenyl)prop-2-enoate

: 1356600-28-6
ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium(II) hydroxide / ethyl acetate / 2 h / 20 °C / 2585.81 Torr

2.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

2.2: 0 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; hydrogen; boron tribromide; triphenylphosphine; palladium(II) hydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1356600-28-6
ethyl 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate; acetic acid / 0.08 h / 20 °C

1.2: 3 h / 20 - 80 °C

2.1: potassium carbonate / acetonitrile / 0.08 h / 20 °C

2.2: 5 h / 20 - 80 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; sodium acetate; potassium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; acetonitrile;