N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

Base Information

Chemical Name:N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride
CAS No.:1449275-15-3
Molecular Formula:C₂₀H₂₅FN₂O₃S*ClH
Molecular Weight:428.955
Hs Code.:

Synonyms:N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

Suppliers and Price of N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

There total 9 articles about N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1449275-13-1
N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide

: 1449275-15-3
N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 20 ℃; for 0.833333h;

Reference yield:

: 920797-21-3
N-benzyl-2-chloro-N-[(2S)-2-(4-fluorophenyl)-2-hydroxyethyl]acetamide

: 1449275-15-3
N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / 1.5 h / 22 °C / Large scale

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 70 °C / Inert atmosphere

2.2: 0.5 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / cis-1,2-Dichloroethylene / 3 h / 70 °C

4.1: triethylamine / dichloromethane / 0.5 h / 22 °C / Inert atmosphere

4.2: 3 h

5.1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 0.83 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; cis-1,2-Dichloroethylene; dichloromethane; isopropyl alcohol;

Reference yield:

: 503860-58-0
(2S)-2-(4-fluorophenyl)morpholine hydrochloride

: 1449275-15-3
N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.5 h / 22 °C / Inert atmosphere

1.2: 3 h

2.1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 0.83 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; isopropyl alcohol;