N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide

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Chemical Name:N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide
CAS No.:1449275-13-1
Molecular Formula:C₂₀H₂₅FN₂O₃S
Molecular Weight:392.495
Hs Code.:

Synonyms:N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide

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Chemical Property of N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide

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Technology Process of N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide

There total 9 articles about N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.13%

: 503860-58-0
(2S)-2-(4-fluorophenyl)morpholine hydrochloride

: 1448682-03-8
N-[(1R)-1-(4-formylphenyl)ethyl]methanesulfonamide

: 1449275-13-1
N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide

Guidance literature:: (2S)-2-(4-fluorophenyl)morpholine hydrochloride; N-[(1R)-1-(4-formylphenyl)ethyl]methanesulfonamide; With triethylamine; In dichloromethane; at 22 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; for 3h;

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1449275-13-1
N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; borane N,N-diethylaniline complex / toluene; tert-butyl methyl ether / 2.5 h / 40 °C / Inert atmosphere; Large scale

1.2: 0.5 h / 10 - 20 °C / Large scale

2.1: sodium hydroxide / water; tert-butyl methyl ether / 3 h / 20 - 22 °C / Large scale

3.1: 21 h / 20 - 80 °C / Inert atmosphere; Large scale

4.1: sodium hydroxide / water; dichloromethane / 0.67 h / 0 - 3 °C / Large scale

4.2: 2 h / 0 - 6 °C / Large scale

5.1: potassium tert-butylate / 1.5 h / 22 °C / Large scale

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 70 °C / Inert atmosphere

6.2: 0.5 h / 0 °C

7.1: carbonochloridic acid 1-chloro-ethyl ester / cis-1,2-Dichloroethylene / 3 h / 70 °C

8.1: triethylamine / dichloromethane / 0.5 h / 22 °C / Inert atmosphere

8.2: 3 h

With lithium aluminium tetrahydride; borane N,N-diethylaniline complex; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; triethylamine; sodium hydroxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; cis-1,2-Dichloroethylene; dichloromethane; tert-butyl methyl ether; water; toluene;

Reference yield:

: 1234372-12-3
(1S)-2-bromo-1-(4-fluorophenyl)ethan-1-ol

: 1449275-13-1
N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / water; tert-butyl methyl ether / 3 h / 20 - 22 °C / Large scale

2.1: 21 h / 20 - 80 °C / Inert atmosphere; Large scale

3.1: sodium hydroxide / water; dichloromethane / 0.67 h / 0 - 3 °C / Large scale

3.2: 2 h / 0 - 6 °C / Large scale

4.1: potassium tert-butylate / 1.5 h / 22 °C / Large scale

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 70 °C / Inert atmosphere

5.2: 0.5 h / 0 °C

6.1: carbonochloridic acid 1-chloro-ethyl ester / cis-1,2-Dichloroethylene / 3 h / 70 °C

7.1: triethylamine / dichloromethane / 0.5 h / 22 °C / Inert atmosphere

7.2: 3 h

With lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; triethylamine; sodium hydroxide; In tetrahydrofuran; cis-1,2-Dichloroethylene; dichloromethane; tert-butyl methyl ether; water;