(E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride

Base Information

Chemical Name:(E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride
CAS No.:1370641-48-7
Molecular Formula:C₁₁H₁₁ClO₂
Molecular Weight:210.66
Hs Code.:

Synonyms:(E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride

Suppliers and Price of (E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride

There total 2 articles about (E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52750-05-7,119870-81-4,115754-00-2
ethyl (E)-3-(4-methoxyphenyl)-2-methylpropenoate

: 1370641-48-7
(E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / Heating

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/anie.201710601

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1370641-48-7
(E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / Heating

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; mineral oil;
DOI:10.1002/anie.201710601

Reference yield: 85.0%

: 1370641-48-7
(E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride

: (E)-ethyl 2-(((2-(trimethylsilyl)ethoxy)methoxy)methylene)butanoate

: (2E,5E)-ethyl 2-ethyl-6-(4-methoxyphenyl)-5-methyl-4-oxo-3-[[2-(trimethylsilyl)ethoxy]methoxy]hexa-2,5-dienoate

Guidance literature:: (E)-ethyl 2-(((2-(trimethylsilyl)ethoxy)methoxy)methylene)butanoate; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 20 ℃; for 0.5h;

With 2CN^(1-)*Cu⁽²⁺⁾*Cl₂Li₂; In tetrahydrofuran; at -30 ℃; for 0.5h;

(E)-3-(4-methoxyphenyl)-2-methylacryloyl chloride; In tetrahydrofuran; at -30 - 10 ℃; for 5h;
DOI:10.1002/anie.201500881