5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite

Base Information

• Chemical Name: 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite
• CAS No.: 144988-68-1
• Molecular Formula: C₄₀H₄₉N₄O₇P
• Molecular Weight: 728.825

Synonyms:5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite

Chemical Property of 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite

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Technology Process of 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite

There total 13 articles about 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

cyanoethyldiisopropylchlorophosphoramidite + 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone (151503-27-4) → 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite (144988-68-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2016.01.041

Reference yield:

2-thiothymidine (28585-51-5) → 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite (144988-68-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine, DMAP

2: m-chloroperbenzoic acid, pyridine / CH₂Cl₂ / 0.17 h

3: diisopropylammonium tetrazolide / CH₂Cl₂

With pyridine; dmap; N,N-diisopropylamine tetrazolide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)79235-5

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite (144988-68-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine, DMAP

2: m-chloroperbenzoic acid, pyridine / CH₂Cl₂ / 0.17 h

3: diisopropylammonium tetrazolide / CH₂Cl₂

With pyridine; dmap; N,N-diisopropylamine tetrazolide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)79235-5

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

4,4'-dimethoxytrityl chloride

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