methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate

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Chemical Name:methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate
CAS No.:1609123-06-9
Molecular Formula:C₂₆H₃₁N₅O₅S
Molecular Weight:525.629
Hs Code.:

Synonyms:methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate

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Chemical Property of methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate

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Technology Process of methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate

There total 6 articles about methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.25%

: 89980-97-2
4-bromomethyl-benzenesulfonic acid methyl ester

: 1609122-94-2
N-(2-isopropoxy-5-(piperazin-1-yl)phenyl)pyrazine-2-carboxamide

: 1609123-06-9
methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2014.03.073

Reference yield:

: 144881-51-6
1-(4-isopropoxyphenyl)piperazine

: 1609123-06-9
methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 °C / Molecular sieve

1.2: 16 h / 0 - 20 °C / Molecular sieve

2.1: 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one / tetrahydrofuran; diethyl ether / 5 h / 20 °C

3.1: hydrogen; palladium 10% on activated carbon; acetic acid / methanol / 24 h / 3102.97 Torr

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Molecular sieve; Inert atmosphere

4.2: 24 h / 20 °C / Inert atmosphere; Molecular sieve

5.1: potassium carbonate / methanol; water / 2 h / Inert atmosphere; Reflux

6.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C

With pyridine; palladium 10% on activated carbon; 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.073

Reference yield:

: 1364525-21-2
C₁₅H₁₉F₃N₂O₂

: 1609123-06-9
methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one / tetrahydrofuran; diethyl ether / 5 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon; acetic acid / methanol / 24 h / 3102.97 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Molecular sieve; Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: potassium carbonate / methanol; water / 2 h / Inert atmosphere; Reflux

5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C

With palladium 10% on activated carbon; 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.073