5-chloro-N₁,N₃-diisobutylisophthalamide

Base Information

• Chemical Name: 5-chloro-N₁,N₃-diisobutylisophthalamide
• CAS No.: 1201663-45-7
• Molecular Formula: C₁₆H₂₃ClN₂O₂
• Molecular Weight: 310.824
• Mol file: 1201663-45-7.mol

Synonyms:5-chloro-N₁,N₃-diisobutylisophthalamide

Chemical Property of 5-chloro-N₁,N₃-diisobutylisophthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-N₁,N₃-diisobutylisophthalamide

There total 1 articles about 5-chloro-N₁,N₃-diisobutylisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-chloro-isophthalic acid (2157-39-3) + isobutylamine (78-81-9) → 5-chloro-N1,N3-diisobutylisophthalamide (1201663-45-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 72.0%

5-chloro-N1,N3-diisobutylisophthalamide (1201663-45-7) → [3-chloro-5-(isobutylamino-methyl)-benzyl]-isobutyl-amine (1201663-46-8)

Guidance literature:

5-chloro-N₁,N₃-diisobutylisophthalamide; With diborane; In tetrahydrofuran; at 20 - 60 ℃; for 38h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; methanol; water; for 2h;

With sodium hydroxide; In water; pH=9;

Reference yield:

5-chloro-N1,N3-diisobutylisophthalamide (1201663-45-7) → tert-butyl 3-chloro-5-((isobutylamino)methyl)benzyl(isobutyl)carbamate (1201663-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diborane / tetrahydrofuran / 38 h / 20 - 60 °C / Inert atmosphere

1.2: 2 h

1.3: pH 9

2.1: acetonitrile / 2 h / 20 °C

With diborane; In tetrahydrofuran; acetonitrile;

upstream raw materials:

5-chloro-isophthalic acid

isobutylamine

Downstream raw materials:

[3-chloro-5-(isobutylamino-methyl)-benzyl]-isobutyl-amine

tert-butyl 3-chloro-5-((isobutylamino)methyl)benzyl(isobutyl)carbamate

3,5-dichloro-N-(3-chloro-5-((isobutylamino)methyl)benzyl)-2-hydroxy-N-isobutylbenzenesulfonamide

tert-butyl 3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl(isobutyl)carbamate

Refernces