(2S,4S)-1-Boc-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-(1-piperazinyl)pyrrolidine

Base Information

• Chemical Name: (2S,4S)-1-Boc-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-(1-piperazinyl)pyrrolidine
• CAS No.: 869489-00-9
• Molecular Formula: C₁₈H₃₀F₂N₄O₃
• Molecular Weight: 388.458
• Mol file: 869489-00-9.mol

Synonyms:(2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property of (2S,4S)-1-Boc-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-(1-piperazinyl)pyrrolidine

Chemical Property:

• Boiling Point: 509.9±50.0 °C(Predicted)
• PKA: 9.16±0.10(Predicted)
• Density: 1.26±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

(2S,4S)-1-Boc-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-(1-piperazinyl)pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S)-1-Boc-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-(1-piperazinyl)pyrrolidine

There total 1 articles about (2S,4S)-1-Boc-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-(1-piperazinyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-[(3S,5S)-1-tert-butoxycarbonyl-5-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidin-3-yl]piperazine-1-carboxylic acid benzyl ester (869489-01-0) → (2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester (869489-00-9)

Guidance literature:

With cyclohexa-1,4-diene; palladium 10% on activated carbon; In ethanol; at 20 ℃;

Reference yield: 100.0%

(2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester (869489-00-9) + 2,4-difluoro-benzoic acid (1583-58-0) → (2S,4S)-4-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-2-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:

(2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester; 2,4-difluoro-benzoic acid; With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

upstream raw materials:

4-[(3S,5S)-1-tert-butoxycarbonyl-5-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidin-3-yl]piperazine-1-carboxylic acid benzyl ester

Refernces