(R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate

Base Information

Chemical Name:(R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate
CAS No.:1427262-83-6
Molecular Formula:C₂₃H₁₇BrF₃N₅O₃
Molecular Weight:548.319
Hs Code.:

Synonyms:(R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate

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Chemical Property of (R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate

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Technology Process of (R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate

There total 9 articles about (R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427262-81-4
(R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate

: 1427262-83-6
(R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate

Guidance literature:: With triethylamine; p-toluenesulfonyl chloride; In chloroform; at 65 ℃; for 2h;

Reference yield:

: 866775-18-0
3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

: 1427262-83-6
(R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / methanol / 20 °C

2: HATU / 1-methyl-pyrrolidin-2-one / 0.75 h / 20 °C

3: triethylamine; p-toluenesulfonyl chloride / chloroform / 2 h / 65 °C

With water; triethylamine; p-toluenesulfonyl chloride; HATU; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; chloroform;

Reference yield:

: 1334546-32-5
3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid

: 1427262-83-6
(R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: HATU / 1-methyl-pyrrolidin-2-one / 0.75 h / 20 °C

2: triethylamine; p-toluenesulfonyl chloride / chloroform / 2 h / 65 °C

With triethylamine; p-toluenesulfonyl chloride; HATU; In 1-methyl-pyrrolidin-2-one; chloroform;