(R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine

Base Information

Chemical Name:(R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine
CAS No.:1427262-80-3
Molecular Formula:C₁₅H₁₁BrF₃N₅O
Molecular Weight:414.184
Hs Code.:

Synonyms:(R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine

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Chemical Property of (R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine

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Technology Process of (R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine

There total 10 articles about (R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427262-83-6
(R)-benzyl (5-(3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)(phenyl)methylcarbamate

: 1427262-80-3
(R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine

Guidance literature:: With trimethylsilyl iodide; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 866775-18-0
3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

: 1427262-80-3
(R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1: water; sodium hydroxide / methanol / 20 °C

2: HATU / 1-methyl-pyrrolidin-2-one / 0.75 h / 20 °C

3: triethylamine; p-toluenesulfonyl chloride / chloroform / 2 h / 65 °C

4: trimethylsilyl iodide / dichloromethane / 20 °C / Inert atmosphere

With trimethylsilyl iodide; water; triethylamine; p-toluenesulfonyl chloride; HATU; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform;

Reference yield:

: 1334546-32-5
3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid

: 1427262-80-3
(R)-2-(5-(amino(phenyl)methyl)-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: HATU / 1-methyl-pyrrolidin-2-one / 0.75 h / 20 °C

2: triethylamine; p-toluenesulfonyl chloride / chloroform / 2 h / 65 °C

3: trimethylsilyl iodide / dichloromethane / 20 °C / Inert atmosphere

With trimethylsilyl iodide; triethylamine; p-toluenesulfonyl chloride; HATU; In 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform;