(R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate

Base Information

Chemical Name:(R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate
CAS No.:1427262-81-4
Molecular Formula:C₂₃H₁₉BrF₃N₅O₄
Molecular Weight:566.334
Hs Code.:

Synonyms:(R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate

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Chemical Property of (R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate

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Technology Process of (R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate

There total 7 articles about (R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334546-32-5
3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid

: (R)-benzyl 2-hydrazinyl-2-oxo-1-phenylethylcarbamate

: 1427262-81-4
(R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate

Guidance literature:: With HATU; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.75h;

Reference yield:

: 866775-18-0
3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

: 1427262-81-4
(R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol / 20 °C

2: HATU / 1-methyl-pyrrolidin-2-one / 0.75 h / 20 °C

With water; HATU; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol;

Reference yield:

: (R)-ethyl 2-(benzyloxycarbonylamino)-2-phenylacetate

: 1427262-81-4
(R)-benzyl 2-(2-(3-amino-6-bromo-5-(trifluoromethyl)picolinoyl)hydrazinyl)-2-oxo-1-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 144 h / 20 °C

1.2: Chiralpak AS column / Resolution of racemate

2.1: HATU / 1-methyl-pyrrolidin-2-one / 0.75 h / 20 °C

With hydrazine hydrate; HATU; In 1-methyl-pyrrolidin-2-one; ethanol;