(S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate

Base Information

Chemical Name:(S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate
CAS No.:1312440-98-4
Molecular Formula:C₂₅H₂₂ClNO₆S
Molecular Weight:499.972
Hs Code.:

Synonyms:(S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate

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Chemical Property of (S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate

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Technology Process of (S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate

There total 7 articles about (S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1147350-75-1,109904-27-0
2-Oxoclopidogrel

: 5538-51-2
O-acetylsalicyloyl chloride

: 1312440-98-4
(S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate

Guidance literature:: 2-Oxoclopidogrel; With triethylamine; In tetrahydrofuran; for 0.166667h;

O-acetylsalicyloyl chloride; In tetrahydrofuran; at 0 - 25 ℃; for 4h;
DOI:10.1021/jm300038c

Reference yield: 21.0%

: 1312441-08-9
(RS)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-2 (4H)-one)-5-acetate

: 141-78-6
ethyl acetate

: 1441-87-8
salicyloyl chloride

: 1312440-98-4
(S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate

Guidance literature:: (RS)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-2 (4H)-one)-5-acetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

salicyloyl chloride; In N,N-dimethyl-formamide; mineral oil; for 2h;

ethyl acetate; In N,N-dimethyl-formamide; mineral oil;

Reference yield: 20.6%

: 527687-26-9
S(+)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-2(4H)-one)-5-acetic acid methyl ester

: 141-78-6
ethyl acetate

: 1441-87-8
salicyloyl chloride

: 1312440-98-4
(S)-methyl 2-(2-chlorophenyl)-2-(2-acetyl-salicylic acyloxy-4,5,6,7-tetrahydro-thieno[3,2-C]pyridine)-5-acetate

Guidance literature:: S(+)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-2(4H)-one)-5-acetic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

salicyloyl chloride; In N,N-dimethyl-formamide; mineral oil; for 2h;

ethyl acetate; In N,N-dimethyl-formamide; mineral oil;