6-iodobenzovesamicol

Base Information

Chemical Name:6-iodobenzovesamicol
CAS No.:139399-80-7
Molecular Formula:C₂₁H₂₄INO
Molecular Weight:433.332
Hs Code.:
Mol file:139399-80-7.mol

Synonyms:2-Naphthalenol,1,2,3,4-tetrahydro-6-iodo-3-(4-phenyl-1-piperidinyl)-, trans- (9CI);2-Naphthalenol, 1,2,3,4-tetrahydro-6-iodo-3-(4-phenyl-1-piperidinyl)-, trans-(?à)-

Suppliers and Price of 6-iodobenzovesamicol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6-iodobenzovesamicol

Chemical Property:

Vapor Pressure:9.95E-12mmHg at 25°C
Boiling Point:522.1°Cat760mmHg
Flash Point:269.6°C
Density:1.49g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-iodobenzovesamicol

There total 6 articles about 6-iodobenzovesamicol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112628-52-1,141436-23-9
(±)-5-amino-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol

: 139399-80-7
(2R,3R)-6-Iodo-3-(4-phenyl-piperidin-1-yl)-1,2,3,4-tetrahydro-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 0.5 h

2: p-TsOH*H₂O, fuming HNO₃ / 3.5 h / 5 °C

3: 6N aq. HCl / 2 h / Heating

4: 1.) NaNO₂, AcOH, 2.) H₃PO₂ / 1.) H₂O, 5 deg C, 1 h, 2.) H₂O, RT, overnight

5: 93 percent / H₂ / 10percent Pd/C / ethyl acetate; ethanol / 2068.6 Torr

6: 1.) NaNO₂, HCl, AcOH, 2.) KI, I₂ / 1.) H₂O, 5-10 deg C, 30 min, 2.) H₂O, 5 deg C, 3 h

With hydrogenchloride; hydrogen; iodine; nitric acid; hypophosphorous acid; toluene-4-sulfonic acid; acetic acid; potassium iodide; sodium nitrite; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm9507486

Reference yield:

: 120447-37-2
(+/-)-trans-5-acetamido-2-hydroxy-3-(4-phenylpiperidino)tetralin

: 139399-80-7
(2R,3R)-6-Iodo-3-(4-phenyl-piperidin-1-yl)-1,2,3,4-tetrahydro-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH*H₂O, fuming HNO₃ / 3.5 h / 5 °C

2: 6N aq. HCl / 2 h / Heating

3: 1.) NaNO₂, AcOH, 2.) H₃PO₂ / 1.) H₂O, 5 deg C, 1 h, 2.) H₂O, RT, overnight

4: 93 percent / H₂ / 10percent Pd/C / ethyl acetate; ethanol / 2068.6 Torr

5: 1.) NaNO₂, HCl, AcOH, 2.) KI, I₂ / 1.) H₂O, 5-10 deg C, 30 min, 2.) H₂O, 5 deg C, 3 h

With hydrogenchloride; hydrogen; iodine; nitric acid; hypophosphorous acid; toluene-4-sulfonic acid; acetic acid; potassium iodide; sodium nitrite; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm9507486

Reference yield:

: (2R,3R)-6-Nitro-3-(4-phenyl-piperidin-1-yl)-1,2,3,4-tetrahydro-naphthalen-2-ol

: 139399-80-7
(2R,3R)-6-Iodo-3-(4-phenyl-piperidin-1-yl)-1,2,3,4-tetrahydro-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / H₂ / 10percent Pd/C / ethyl acetate; ethanol / 2068.6 Torr

2: 1.) NaNO₂, HCl, AcOH, 2.) KI, I₂ / 1.) H₂O, 5-10 deg C, 30 min, 2.) H₂O, 5 deg C, 3 h

With hydrogenchloride; hydrogen; iodine; acetic acid; potassium iodide; sodium nitrite; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm9507486