5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

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Chemical Name:5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS No.:1451149-99-7
Molecular Formula:C₁₉H₂₁N₃O₂S
Molecular Weight:355.461
Hs Code.:

Synonyms:5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

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Chemical Property of 5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

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Technology Process of 5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

There total 5 articles about 5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1451149-86-2
2-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]-N-cyclohexylhydrazinecarbothioamid

: 1451149-99-7
5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

Guidance literature:: With sodium hydroxide; In water; for 0.5h; Microwave irradiation;
DOI:10.3390/molecules18066366

Reference yield:

: 94-62-2,7780-20-3
Piperine

: 1451149-99-7
5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / ethanol / 1 h / Microwave irradiation

2: oxalyl dichloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: hydrazine hydrate / dichloromethane / 0.5 h / 20 °C / Cooling with ice

4: ethanol / 0.5 h / Microwave irradiation

5: sodium hydroxide / water / 0.5 h / Microwave irradiation

With oxalyl dichloride; hydrazine hydrate; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.3390/molecules18066366

Reference yield:

: 1451149-80-6
(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienehydrazide

: 1451149-99-7
5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-4-cyclohexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 0.5 h / Microwave irradiation

2: sodium hydroxide / water / 0.5 h / Microwave irradiation

With sodium hydroxide; In ethanol; water;
DOI:10.3390/molecules18066366