(2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

Base Information

• Chemical Name: (2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone
• CAS No.: 898838-03-4
• Molecular Formula: C₂₆H₃₀N₂O₆
• Molecular Weight: 466.534
• Mol file: 898838-03-4.mol

Synonyms:(2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

Chemical Property of (2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

There total 9 articles about (2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-isobutyl-3-methoxymethoxy-pyridin-4-yl)-[5-methoxy-4-(4-methoxy-benzyloxy)-pyridin-2-yl]-methanol (1026170-93-3) → (2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone (898838-03-4)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1021/ol061002c

Reference yield:

2-bromo-pyridin-3-ol (6602-32-0) → (2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone (898838-03-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 68 percent / anhydrous potassium carbonate / dimethylformamide / 5 - 20 °C

2.1: 59 percent / [1,3-bis(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 1 h / Heating

3.1: tert-butyllithium / diethyl ether; pentane / 0.75 h / -78 °C

3.2: 1.79 g / diethyl ether; pentane; tetrahydrofuran / 2.25 h / -78 - 20 °C

4.1: 0.77 g / o-iodoxybenzoic acid / dimethylsulfoxide / 2 h / 20 °C

With tert.-butyl lithium; potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; [1,3-bis(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; pentane; 2.1: Kumada cross-coupling;

DOI:10.1021/ol061002c

Reference yield:

2-Bromo-3-(methoxymethoxy)pyridine (162271-10-5) → (2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone (898838-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 59 percent / [1,3-bis(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 1 h / Heating

2.1: tert-butyllithium / diethyl ether; pentane / 0.75 h / -78 °C

2.2: 1.79 g / diethyl ether; pentane; tetrahydrofuran / 2.25 h / -78 - 20 °C

3.1: 0.77 g / o-iodoxybenzoic acid / dimethylsulfoxide / 2 h / 20 °C

With tert.-butyl lithium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; [1,3-bis(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; dimethyl sulfoxide; pentane; 1.1: Kumada cross-coupling;

DOI:10.1021/ol061002c

upstream raw materials:

(2-isobutyl-3-methoxymethoxy-pyridin-4-yl)-[5-methoxy-4-(4-methoxy-benzyloxy)-pyridin-2-yl]-methanol

2-isobutyl-3-(methoxymethoxy)pyridine

5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinecarboxaldehyde

[5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl]methanol

Downstream raw materials:

(3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate