benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

Base Information

• Chemical Name: benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate
• CAS No.: 1104449-57-1
• Molecular Formula: C₁₉H₂₂N₂O₄
• Molecular Weight: 342.395
• Mol file: 1104449-57-1.mol

Synonyms:benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

Chemical Property of benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

There total 1 articles about benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5) → benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate (1104449-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm501175v

Reference yield: 49.0%

benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate (1104449-57-1) + 4-bromoohenyl methyl sulfone (3466-32-8) → benzyl 4-((5-methyl-1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)piperidine-1-carboxylate (1104449-52-6)

Guidance literature:

With potassium carbonate; copper(l) iodide; In dimethyl sulfoxide; at 100 ℃; for 16h;

Reference yield:

benzyl 4-(5-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate (1104449-57-1) → 5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one (1104451-76-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 16 h / 100 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / Inert atmosphere; Sealed tube

3.2: 16 h / 20 °C / Inert atmosphere; Reflux

With copper(l) iodide; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm501175v

upstream raw materials:

1-(benzyloxycarbonyl)-4-hydroxypiperidine

Downstream raw materials:

benzyl 4-((5-methyl-1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)piperidine-1-carboxylate

5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one

5-methyl 1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one