(6R)-3,4t-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:(6R)-3,4t-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester
CAS No.:33277-67-7
Molecular Formula:C₁₉H₁₉Cl₃N₂O₅S
Molecular Weight:493.795
Hs Code.:

(6<i>R</i>)-3,4<i>t</i>-dimethyl-8-oxo-7<i>t</i>-(2-phenoxy-acetylamino)-(6<i>r</i><i>H</i>)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Synonyms:(6R)-3,4t-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of (6R)-3,4t-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

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Technology Process of (6R)-3,4t-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 3 articles about (6R)-3,4t-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33213-50-2
2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

: 33277-67-7
(6R)-3,4t-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Rh-C / ethyl acetate; acetic acid

2: SnCl₂, AcCl / CH₂Cl₂; acetonitrile

With hydrogen; acetyl chloride; tin(ll) chloride; Rh on carbon; In dichloromethane; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1021/jm00287a011

Reference yield:

: 27250-45-9
(6R)-3-methyl-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

: 33277-67-7
(6R)-3,4t-dimethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Me₂NH*HCl / CH₂Cl₂; 2-methyl-propan-2-ol; H₂O

2: H₂ / Rh-C / ethyl acetate; acetic acid

3: SnCl₂, AcCl / CH₂Cl₂; acetonitrile

With hydrogen; N,N-dimethylammonium chloride; acetyl chloride; tin(ll) chloride; Rh on carbon; In dichloromethane; water; acetic acid; ethyl acetate; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm00287a011