2,4,5-Trimethoxy-3-isopropylbenzyl bromide

Base Information

• Chemical Name: 2,4,5-Trimethoxy-3-isopropylbenzyl bromide
• CAS No.: 144707-43-7
• Molecular Formula: C₁₃H₁₉BrO₃
• Molecular Weight: 303.196
• Mol file: 144707-43-7.mol

Synonyms:2,4,5-Trimethoxy-3-isopropylbenzyl bromide

Chemical Property of 2,4,5-Trimethoxy-3-isopropylbenzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-Trimethoxy-3-isopropylbenzyl bromide

There total 8 articles about 2,4,5-Trimethoxy-3-isopropylbenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(3-isopropyl-2,4,5-trimethoxyphenyl)methanol (144707-42-6) → 2,4,5-Trimethoxy-3-isopropylbenzyl bromide (144707-43-7)

Guidance literature:

With pyridine; phosphorus tribromide; In benzene; for 3h;

Reference yield:

1,3-dimethoxy-2-(1-hydroxy-1-methylethyl)benzene (16929-70-7) → 2,4,5-Trimethoxy-3-isopropylbenzyl bromide (144707-43-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 98 percent / glacial HOAc / 2 h / Heating

2: 97 percent / H₂ / 5percent Pd/C / diethyl ether / 19 h / 2068.6 Torr

3: m-CPBA / CH₂Cl₂ / Ambient temperature

4: 88 percent / K₂CO₃ / acetone / 120 h / Heating

5: 88 percent / KBr, 18-crown-6, m-CPBA / CH₂Cl₂ / 0.5 h

6: 1) Mg / 1) THF, 2) cooling, then reflux, 5 min

7: 100 percent / NaBH₄ / methanol / 0.25 h / 0 °C

8: 96 percent / PBr₃, pyridine / benzene / 3 h

With pyridine; sodium tetrahydroborate; 18-crown-6 ether; hydrogen; phosphorus tribromide; potassium carbonate; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium bromide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; acetone; benzene;

Reference yield:

methyl 2,6-dimethoxybenzoate (2065-27-2) → 2,4,5-Trimethoxy-3-isopropylbenzyl bromide (144707-43-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 94 percent / diethyl ether / 0.17 h / Heating

2: 98 percent / glacial HOAc / 2 h / Heating

3: 97 percent / H₂ / 5percent Pd/C / diethyl ether / 19 h / 2068.6 Torr

4: m-CPBA / CH₂Cl₂ / Ambient temperature

5: 88 percent / K₂CO₃ / acetone / 120 h / Heating

6: 88 percent / KBr, 18-crown-6, m-CPBA / CH₂Cl₂ / 0.5 h

7: 1) Mg / 1) THF, 2) cooling, then reflux, 5 min

8: 100 percent / NaBH₄ / methanol / 0.25 h / 0 °C

9: 96 percent / PBr₃, pyridine / benzene / 3 h

With pyridine; sodium tetrahydroborate; 18-crown-6 ether; hydrogen; phosphorus tribromide; potassium carbonate; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium bromide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; acetone; benzene;

upstream raw materials:

(3-isopropyl-2,4,5-trimethoxyphenyl)methanol

3-(1-methylethyl)-1,2,4-trimethoxybenzene

methyl 2,6-dimethoxybenzoate

1,3-dimethoxy-2-(1-hydroxy-1-methylethyl)benzene

Downstream raw materials:

2,4,5-Trimethoxy-3-isopropylphenylacetonitrile

2-Geranyl-2-(2,4,5-trimethoxy-3-isopropylphenyl)acetonitrile