N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide

Base Information

• Chemical Name: N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide
• CAS No.: 930797-71-0
• Molecular Formula: C₁₆H₁₈N₂O₅S
• Molecular Weight: 350.395
• Mol file: 930797-71-0.mol

Synonyms:N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide

Chemical Property of N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide

There total 8 articles about N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(2,5-dimethylbenzyloxy)-4-nitroaniline (930797-62-9) + methanesulfonyl chloride (124-63-0) → N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide (930797-71-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2009.09.109

Reference yield: 93.0%

→ N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide (930797-71-0)

Guidance literature:

Reference yield:

5-Nitro-2-aminophenol (121-88-0) → N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide (930797-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 93 percent / K₂CO₃ / dimethylformamide / 3 h / 75 - 80 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: dimethylformamide / 20 °C

3.1: aq. NaOH / 80 - 90 °C

With sodium hydroxide; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm061133j

upstream raw materials:

C₁₇H₂₀N₂O₇S₂

2-(2,5-dimethylbenzyloxy)-4-nitroaniline

2,5-dimethylbenzyl chloride

5-Nitro-2-aminophenol

Downstream raw materials:

C₁₆H₂₀N₂O₃S

benzo[1,3]dioxole-5-carboxylic acid {3-(2,5-dimethylbenzyloxy)-4-[(6-hydroxyhexyl)methanesulfonylamino]phenyl}amide

benzo[1,3]dioxole-5-carboxylic acid [3-(2,5-dimethylbenzyloxy)-4-(methanesulfonylamino)phenyl]amide

N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]isoxazole-5-carboxamide