N¹-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide

Base Information

• Chemical Name: N¹-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide
• CAS No.: 438012-60-3
• Molecular Formula: C₂₁H₃₃N₅O₆S
• Molecular Weight: 483.589
• Mol file: 438012-60-3.mol

Synonyms:N¹-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide

Chemical Property of N¹-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide

There total 7 articles about N¹-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

toluene-4-sulfonamide (70-55-3) + N-[2-(allyloxycarbonyl)ethyl]-N'-[2-(tert-butyloxycarbonyl)-ethyl]-S-methylthiouronium hexafluorophosphate → N1-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide (438012-60-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In chloroform; toluene; for 24h; Heating;

DOI:10.1002/1521-3765(20020315)8:6<1424::AID-CHEM1424>3.0.CO;2-Z

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N1-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide (438012-60-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / CH₂Cl₂ / 24 h / 20 °C

2.1: 72 percent / CHCl₃ / 18 h / Heating

3.1: acetone / 18 h / 20 °C

3.2: 96 percent / NH₄PF₆ / CH₂Cl₂; methanol / 18 h / 20 °C

4.1: 92 percent / DBU / toluene; CHCl₃ / 24 h / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; chloroform; acetone; toluene;

DOI:10.1002/1521-3765(20020315)8:6<1424::AID-CHEM1424>3.0.CO;2-Z

Reference yield:

N-BOC-1,2-diaminoethane (57260-73-8) → N1-[1-[2'-(allyloxycarbonyl)ethylamino]-1-[2''-(tert-butyloxycarbonyl)ethylamino]methylidene]-4-methyl-1-benzenesulfonamide (438012-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 72 percent / CHCl₃ / 18 h / Heating

2.1: acetone / 18 h / 20 °C

2.2: 96 percent / NH₄PF₆ / CH₂Cl₂; methanol / 18 h / 20 °C

3.1: 92 percent / DBU / toluene; CHCl₃ / 24 h / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In chloroform; acetone; toluene;

DOI:10.1002/1521-3765(20020315)8:6<1424::AID-CHEM1424>3.0.CO;2-Z

upstream raw materials:

toluene-4-sulfonamide

di-tert-butyl dicarbonate

N-BOC-1,2-diaminoethane

(2-isothiocyanatoethyl)carbamic acid allyl ester

Downstream raw materials:

N₁-{1-[2'-(tert-butyloxycarbonyl)ethylamino]-1-[2''-[(9H-fluorenyl)methoxycarbonyl]ethylamino]methylidene}-4-methyl-1-benzenesulfonamide

tert-butyl (4S)-5-({2-[([(2-{[(allyloxy)carbonyl]amino}ethyl)-amino]{[(4-methylphenyl)sulfonyl]imino}methyl)amino]ethyl}-amino)-4-{[(9H-fluorenylmethyloxy)carbonyl]amino}-5-oxo-pentanoate