N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide

Base Information

Chemical Name:N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide
CAS No.:386210-72-6
Molecular Formula:C₇₂H₈₉Cl₄NO₁₃
Molecular Weight:1318.31
Hs Code.:

N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide

Synonyms:N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide

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Chemical Property of N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide

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Technology Process of N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide

There total 3 articles about N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 207743-06-4
3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-3,3-diphenylpropenoic acid

: 386210-68-0
N-(5α-cholestan-3β-yl)-6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenylamine

: 386210-72-6
N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1016/S0968-0896(01)00152-3

Reference yield:

: 3β-amino-5α-cholestane hydrochloride

: 386210-72-6
N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89.3 percent / triethylamine; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 24 h / 20 °C

2: 84 percent / triethylamine; 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 48 h / 20 °C

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00152-3

Reference yield:

: 252934-37-5
C₂₄H₂₄Cl₂O₇

: 386210-72-6
N-(5α-cholestan-3β-yl)-N-[6,6-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-5-hexenyl]-3,3-bis(3'-methoxycarbonyl-5'-chloro-4'-methoxyphenyl)-2-propenamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89.3 percent / triethylamine; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 24 h / 20 °C

2: 84 percent / triethylamine; 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 48 h / 20 °C

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00152-3