4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide

Base Information

Chemical Name:4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide
CAS No.:862081-57-0
Molecular Formula:C₃₃H₃₆N₂O₄
Molecular Weight:524.66
Hs Code.:

Synonyms:4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide

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Chemical Property of 4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide

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Technology Process of 4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide

There total 7 articles about 4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 648904-46-5
trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-yl ester

: 405520-68-5
4-(N,N-dimethylaminocarbonyl)phenylboronic acid

: 862081-57-0
4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide

Guidance literature:: With cesium fluoride; tricyclohexylphosphine; palladium diacetate;
DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

: 648904-47-6
2-(benzyloxy)-1-bromo-6-methoxynaphthalene

: 862081-57-0
4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 30 percent / copper triflate

2: NH₄HCO₂ / Pd(OH)2

3: PCy₃; CsF / Pd(OAc)2

With ammonium formate; copper(I) triflate; cesium fluoride; tricyclohexylphosphine; palladium diacetate; palladium dihydroxide; 1: Ullman coupling / 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

: 648904-49-8
6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalene-2-ol

: 862081-57-0
4-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: PCy₃; CsF / Pd(OAc)2

With cesium fluoride; tricyclohexylphosphine; palladium diacetate; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044