648904-46-5

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 6-methoxy-1-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-naphthalenyl ester
• Synonyms: trifluoro-methanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl ester;trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl ester;6-methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate
• CAS NO: 648904-46-5
• Molecular Formula: C25H26F3NO6S
• Molecular Weight: 525.546
• Mol File: 648904-46-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 6-methoxy-1-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-naphthalenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 6-methoxy-1-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-naphthalenyl ester(648904-46-5)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 6-methoxy-1-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-naphthalenyl ester(648904-46-5)

Safety Data

• Hazardous Substances Data: 648904-46-5(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 194594-62-2 1-bromo-6-methoxynaphthalen-2-ol 
• 5111-66-0 6-Methoxy-2-naphthol 
• 648904-48-7 1-{2-[4-(2-benzyloxy-6-methoxynaphthalen-1-yloxy)phenoxy]ethyl}piperidine 
• 648904-47-6 2-(benzyloxy)-1-bromo-6-methoxynaphthalene 
• 648904-49-8 6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalene-2-ol 
• 100238-42-4 4-(2-piperidin-1-yl-ethoxy)-phenol 

Downstream Products

• 866346-49-8 1-(2-{4-[2-(4-fluorophenyl)-6-methoxynaphthalen-1-yloxy]phenoxy}ethyl)piperidine 
• 861930-46-3 6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol 
• 862130-05-0 6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol 
• 862129-82-6 1-(2-{4-[2-(1,1-dioxo-1,2,3,6-tetrahydro-1λ6-thiopyran-4-yl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine 
• 770708-13-9 4-{6-hydroxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethylbenzenesulfonamide 
• 648904-79-4 6-(4-ethanesulfonyl-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol 
• 648905-29-7 5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-6-[4-(propane-2-sulfonyl)-phenyl]-naphthalen-2-ol 
• 862081-59-2 4-{6-hydroxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-N,N-dimethyl-benzamide 
• 861930-36-1 6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol 
• 862129-85-9 6-(1,1-dioxo-1,2,3,6-tetrahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol 
• 862130-04-9 6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol 
• 862129-77-9 (+/-)-6-(4-methanesulfonyl-cyclohex-1-enyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol 
• 1219628-67-7 trifluoro-methanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl ester hydrochloride 
• 648904-50-1 trifluoro-methanesulfonic acid 6-hydroxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl ester 

Relevant articles and documents

SELECTIVE ESTROGEN RECEPTOR MODULATOR

The present invention is directed to a compound of the formula (A): or a pharmaceutically acceptable salt thereof; and also to compounds of formula (I): or a pharmaceutically acceptable salt thereof.

SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS

The present invention relates to a selective estrogen receptor modulator of formula I or Ia: (I) (Ia); or a pharmaceutical acid addition salt thereof; useful for treating vasomotor symptoms, in particular hot flashes, night sweats and other symptoms that affect women around menopause.

SELECTIVE ESTROGEN RECEPTOR MODULATORS

The present invention relates to a selective estrogen receptor modulator of formula I: or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and uterine leiomyoma.