5-[2-((4aR,6S,7R,8R,8aR)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethylcarbamoyl]-pentanoic acid methyl ester

Base Information

Chemical Name:5-[2-((4aR,6S,7R,8R,8aR)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethylcarbamoyl]-pentanoic acid methyl ester
CAS No.:78632-92-5
Molecular Formula:C₂₄H₃₄N₂O₉
Molecular Weight:494.542
Hs Code.:

Synonyms:5-[2-((4aR,6S,7R,8R,8aR)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethylcarbamoyl]-pentanoic acid methyl ester

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Chemical Property of 5-[2-((4aR,6S,7R,8R,8aR)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethylcarbamoyl]-pentanoic acid methyl ester

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Technology Process of 5-[2-((4aR,6S,7R,8R,8aR)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethylcarbamoyl]-pentanoic acid methyl ester

There total 14 articles about 5-[2-((4aR,6S,7R,8R,8aR)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethylcarbamoyl]-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 100-52-7
benzaldehyde

: 78632-91-4
<2-(4-Methoxycarbonylbutancarboxamido)ethyl>-2-acetamido-2-desoxy-α-D-galactopyranosid

: 78632-92-5
5-[2-((4aR,6S,7R,8R,8aR)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethylcarbamoyl]-pentanoic acid methyl ester

Guidance literature:: DOI:10.1016/S0040-4039(01)90328-4

Reference yield:

: 67817-37-2
3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl chloride

: 78632-92-5,78632-96-9
<2-(4-Methoxycarbonylbutancarboxamido)ethyl>-2-acetamido-4,6-O-benzyliden-2-desoxy-α-D-galactopyranosid

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Ag₂CO₃, CF₃SO₃Ag, molecular sieves / 1) CH₂Cl₂, toluene, 2 h; 2) CH₂Cl₂, toluene, 2 d, room temperature

2: 2.41 g / 60percent acetic acid / H₂O / 0.25 h / 80 °C

3: dicyclohexylcarbodiimid / dimethylformamide / 5 h / 0 °C

4: 1) zinc; 2) sodium / 1) acetic acid, room temperature, 30 min; 2) methanol, room temperature, 1 h

5: zinc chloride / neat (no solvent) / 24 h

With molecular sieve; silver trifluoromethanesulfonate; sodium; acetic acid; dicyclohexyl-carbodiimide; silver carbonate; zinc(II) chloride; zinc; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)82583-5

Reference yield:

: 67817-37-2
3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl chloride

: 78632-92-5,78632-96-9
<2-(4-Methoxycarbonylbutancarboxamido)ethyl>-2-acetamido-4,6-O-benzyliden-2-desoxy-β-D-galactopyranosyd

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Ag₂CO₃, CF₃SO₃Ag, molecular sieves / 1) CH₂Cl₂, toluene, 2 h; 2) CH₂Cl₂, toluene, 2 d, room temperature

2: 2.41 g / 60percent acetic acid / H₂O / 0.25 h / 80 °C

3: dicyclohexylcarbodiimid / dimethylformamide / 5 h / 0 °C

4: 1) zinc; 2) sodium / 1) acetic acid, room temperature, 30 min; 2) methanol, room temperature, 1 h

5: zinc chloride / neat (no solvent) / 24 h

With molecular sieve; silver trifluoromethanesulfonate; sodium; acetic acid; dicyclohexyl-carbodiimide; silver carbonate; zinc(II) chloride; zinc; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)82583-5