5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one

Base Information

Chemical Name:5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one
CAS No.:1333146-51-2
Molecular Formula:C₁₃H₇ClF₅NO₂
Molecular Weight:339.649
Hs Code.:

Synonyms:5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one

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Chemical Property of 5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one

Chemical Property:

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Technology Process of 5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one

There total 4 articles about 5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333146-95-4
C₂₀H₁₃ClF₅NO₂

: 1333146-51-2
5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one

Guidance literature:: With boron trifluoride diethyl etherate; ethanethiol; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 286946-77-8
5-bromo-2-chloro-3-hydroxypyridine

: 1333146-51-2
5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: sodium hydrogencarbonate / acetonitrile / 50 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.33 h / 150 °C / Irradiation

4: boron trifluoride diethyl etherate; ethanethiol / dichloromethane / 3 h / 20 °C

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; caesium carbonate; ethanethiol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 891785-18-5
3-(benzyloxy)-5-bromo-2-chloropyridine

: 1333146-51-2
5-[4-chloro-3-(trifluoromethyl)phenyl]-1-(difluoromethyl)-3-hydroxypyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / acetonitrile / 50 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.33 h / 150 °C / Irradiation

3: boron trifluoride diethyl etherate; ethanethiol / dichloromethane / 3 h / 20 °C

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; caesium carbonate; ethanethiol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water; acetonitrile;