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Usage

Uses

Used in Pharmaceutical Synthesis:
3-(Benzyloxy)-5-bromo-2-chloropyridine is used as an intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the creation of biologically active compounds, contributing to the development of new medications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 3-(Benzyloxy)-5-bromo-2-chloropyridine serves as a key intermediate in the production of pesticides and other crop protection agents. Its role in synthesizing effective and targeted agrochemicals supports agricultural productivity and crop protection.
Used in Organic Synthesis:
3-(Benzyloxy)-5-bromo-2-chloropyridine is utilized as a building block in organic synthesis, enabling the creation of a wide range of chemical compounds. Its versatility and reactivity make it an important component in the development of new organic molecules for various applications.
Used in Medicinal Research:
3-(Benzyloxy)-5-broMo-2-chloropyridine is employed in medicinal research as a precursor to various biologically active molecules. Its structural features facilitate the exploration of new drug candidates and contribute to the advancement of medical science.
Used in Agricultural Research:
3-(Benzyloxy)-5-bromo-2-chloropyridine is also used in agricultural research to develop new agrochemicals with improved efficacy and selectivity. Its role in the synthesis of active ingredients for crop protection agents supports sustainable agriculture and pest management strategies.

InChI:InChI=1S/C12H9BrClNO/c13-10-6-11(12(14)15-7-10)16-8-9-4-2-1-3-5-9/h1-7H,8H2

Upstream product

• 552330-34-4 5-bromo-3-(benzyloxy)pyridine N-oxide 
• 625-92-3 3,5-dibromopyridine 
• 130722-95-1 3-(benzyloxy)-5-bromopyridine 
• 100-51-6 benzyl alcohol 
• 754230-78-9 3-(benzyloxy)-5-bromopyridine-2-amine 
• 24016-03-3 2-amino-3-benzyloxypyridine 
• 286946-77-8 5-bromo-2-chloro-3-hydroxypyridine 
• 100-39-0 benzyl bromide 

Downstream Products

• 1314026-59-9 ethyl 3-amino-6-(3-{[(3-chlorophenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-60-2 ethyl 3-amino-6-(3-{[(3-fluorophenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-61-3 ethyl 3-amino-6-(3-{[(3-biphenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-62-4 ethyl 3-amino-6-(3-{[(4-chlorophenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-63-5 ethyl 3-amino-6-(3-{[(4-fluorophenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-64-6 ethyl 3-amino-6-(3-{[(4-biphenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-65-7 ethyl 3-amino-6-(4-{[(3-chlorophenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-66-8 ethyl 3-amino-6-(4-{[(3-biphenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-67-9 ethyl 3-amino-6-(4-{[(4-biphenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate 
• 1314026-68-0 3-amino-6-(3-{[(3-chlorophenyl)amino]carbonyl}phenyl)-N-methylfuro[3,2-b]pyridine-2-carboxamide 
• 1314026-69-1 3-amino-6-(3-{[(3-fluorophenyl)amino]carbonyl}phenyl)-N-methylfuro[3,2-b]pyridine-2-carboxamide 
• 1314026-70-4 3-amino-6-(3-{[(3-biphenyl)amino]carbonyl}phenyl)-N-methylfuro[3,2-b]pyridine-2-carboxamide 
• 1314026-71-5 3-amino-6-(3-{[(4-chlorophenyl)amino]carbonyl}phenyl)-N-methylfuro[3,2-b]pyridine-2-carboxamide 
• 1314026-72-6 3-amino-6-(3-{[(4-fluorophenyl)amino]carbonyl}phenyl)-N-methylfuro[3,2-b]pyridine-2-carboxamide 

Relevant academic research and scientific papers

NITROGEN-CONTAINING HETEROARYL COMPOUND AND PHARMACEUTICAL USE THEREOF

The invention provides a compound having a GLUT9 inhibitory activity. The compound is of Formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS

The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. Th

A convenient route to functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2- carboxamides

The synthesis of novel functionalized 3-amino-N-methylfuro[3,2-b]pyridine- 2-carboxamides is described from cyanopyridine intermediates. Based on the difference in halogen reactivity, ethyl [(5-bromo-2-chloropyridin-3-yl)oxy] acetate was functionalized by a palladium-catalyzed reaction, before the cyclization to the desired furo[3,2-b]pyridines.

Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals

A practical and rapid preparation of 3-benzyloxy-4-bromo and 3-benzyloxy-5-bromopicolinate esters 10 and 16 was developed in four steps, respectively, in 38% and 31% overall yield. Then their viability as partners for cross-coupling reactions has been evaluated in Suzuki-Miyaura, Hartwig-Buchwald, and Sonogashira reactions to synthesize biologically relevant targets. The preparation of these two highly functionalizable pyridines 10 and 16 has been never described to date in the literature and could be used as common building block for the preparation of several biologically active compounds or agrochemical products.

Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity

The structure-activity relationships of a series of isoquinoline-pyridine-based protein kinase B/Akt antagonists have been investigated in an effort to improve the major short-comings of the lead compound 3, including poor pharmacokinetic profiles in several species (e.g., mouse iv t1/2 = 0.3 h, po F = 0%). Chlorination at C-1 position of the isoquinoline improved its pharmacokinetic property in mice (iv t1/2 = 5.0 h, po F = 51%) but resulted in >500-fold drop in potency. In a mouse MiaPaCa-2 xenograft model, an amino analog 10y significantly slowed the tumor growth, however was accompanied by toxicity.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.