1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl]-amide

Base Information

Chemical Name:1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide
CAS No.:1044558-77-1
Molecular Formula:C₃₃H₄₁N₅O₇S
Molecular Weight:651.784
Hs Code.:

1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide

Synonyms:1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide

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Chemical Property of 1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide

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Technology Process of 1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide

There total 14 articles about 1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 669008-26-8
1-methylcyclopropane-1-sulfonamide

: 1044560-05-5
17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid

: 1044558-77-1
1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide

Guidance literature:: 17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

1-methylcyclopropane-1-sulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;

Reference yield:

: 862174-60-5
(1R,4R,5R)-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid

: 1044558-77-1
1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1.17 h / -10 °C

2.1: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

4.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

5.1: triethylsilane; trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

7.1: dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III) / 1,2-dichloro-ethane / Heating / reflux

8.1: methanol; lithium hydroxide; water / tetrahydrofuran / 72 h / 60 °C

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

9.2: 20 °C

With methanol; triethylsilane; lithium hydroxide; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 259214-54-5,259214-56-7
ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

: 1044558-77-1
1-methyl-cyclopropanesulfonic acid [17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

2.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

5.1: dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III) / 1,2-dichloro-ethane / Heating / reflux

6.1: methanol; lithium hydroxide; water / tetrahydrofuran / 72 h / 60 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

7.2: 20 °C

With methanol; triethylsilane; lithium hydroxide; di-isopropyl azodicarboxylate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;