17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

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Chemical Name:17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid
CAS No.:1044560-05-5
Molecular Formula:C₂₉H₃₄N₄O₆
Molecular Weight:534.612
Hs Code.:

Synonyms:17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid

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Chemical Property of 17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid

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Technology Process of 17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid

There total 13 articles about 17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1044560-02-2
17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester

: 1044560-05-5
17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid

Guidance literature:: 17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 60 ℃; for 72h;

With citric acid; In tetrahydrofuran; methanol; water;

Reference yield:

: 259214-54-5,259214-56-7
ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

: 1044560-05-5
17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3: triethylsilane; trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

5: dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III) / 1,2-dichloro-ethane / Heating / reflux

6: methanol; lithium hydroxide; water / tetrahydrofuran / 72 h / 60 °C

With methanol; triethylsilane; lithium hydroxide; di-isopropyl azodicarboxylate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 862174-61-6
3-oxo-2-oxa-bicyclo[2.2.1]heptane-5-carboxylic acid tert-butyl ester

: 1044560-05-5
17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

3: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: triethylsilane; trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

6: dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III) / 1,2-dichloro-ethane / Heating / reflux

7: methanol; lithium hydroxide; water / tetrahydrofuran / 72 h / 60 °C

With methanol; triethylsilane; lithium hydroxide; di-isopropyl azodicarboxylate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;