Technology Process of Cyclohexanecarboxylic acid, 2-[[(phenylmethoxy)carbonyl]amino]-,
(1R,2R)-
There total 10 articles about Cyclohexanecarboxylic acid, 2-[[(phenylmethoxy)carbonyl]amino]-,
(1R,2R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
methanol; water;
at 20 ℃;
for 24h;
DOI:10.1021/jo000277h
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2 / 10percent Pd/C / methanol / 18 h / 2585.81 Torr
2: K2CO3 / dioxane; H2O / pH 9.0
3: 70 percent / NaOMe / methanol / 5 h / Heating
4: 4N HCl / dioxane / 1 h
5: 0.22 g / DIEA; DMAP / CH2Cl2 / 26 h
6: 87 percent / LiOH; 26percent H2O2 / methanol; H2O / 24 h / 20 °C
With
hydrogenchloride; dmap; lithium hydroxide; hydrogen; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine;
10percent Pd/C;
In
1,4-dioxane; methanol; dichloromethane; water;
1: Catalytic hydrogenation / 2: Acylation / 3: Isomerization / 4: Boc-deprotection / 5: Acylation / 6: Hydrolysis;
DOI:10.1021/jo000277h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 0.22 g / DIEA; DMAP / CH2Cl2 / 26 h
2: 87 percent / LiOH; 26percent H2O2 / methanol; H2O / 24 h / 20 °C
With
dmap; lithium hydroxide; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; water;
1: Acylation / 2: Hydrolysis;
DOI:10.1021/jo000277h
