N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide

Base Information

Chemical Name:N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide
CAS No.:1616074-73-7
Molecular Formula:C₂₀H₂₃FN₂O₃
Molecular Weight:358.413
Hs Code.:

Synonyms:N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide

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Chemical Property of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide

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Technology Process of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide

There total 4 articles about N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.6%

: 404-98-8
3-fluorophenoxyacetic acid

: 954279-15-3
1-amino-3-(3,4-dihydroisoquinoline-2(1H)-yl)propan-2-ol

: 1616074-73-7
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 16h;

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1616074-73-7
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 1 h / 0 °C

1.2: 16 h / 22 °C

2.1: ammonia / ethanol / 3 h / -78 - 80 °C / Sealed tube

3.1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 16 h / 25 °C

With ammonia; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 372-20-3
3-fluorophenol

: 1616074-73-7
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-fluorophenoxy)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 4 h / 80 °C

1.2: 4 h / 50 °C

2.1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 16 h / 25 °C

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;