1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile

Base Information

Chemical Name:1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile
CAS No.:139017-66-6
Molecular Formula:C₁₈H₂₀N₂O₃
Molecular Weight:312.368
Hs Code.:

Synonyms:1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile

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Chemical Property of 1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile

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Technology Process of 1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile

There total 2 articles about 1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 6714-68-7
spiro[1,3-dioxolane-2,3'-indolin]-2'-one

: 112905-95-0
1-(chloromethyl)cyclohexanecarbonitrile

: 139017-66-6
1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 130 ℃; for 24h;
DOI:10.1021/jm00085a001

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 139017-66-6
1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / toluenesulfonic acid monohydrate / benzene / 5 h / Heating

2: 46 percent / t-BuOK / dimethylsulfoxide / 24 h / 130 °C

With potassium tert-butylate; toluene-4-sulfonic acid; In dimethyl sulfoxide; benzene;
DOI:10.1021/jm00085a001

Reference yield:

: 139017-66-6
1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile

: 112905-88-1,112905-93-8,112905-94-9
2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cyclohexane-1,3'-pyrimido(1,2-a)indole]

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / H₂, NH₃, Raney nickel / ethanol / 2 h / 50 °C / 3040 - 3800 Torr

2: 93 percent / conc. H₂SO₄ / 1 h / Ambient temperature

3: 46 percent / diethyl ether; 1,2-dichloro-ethane / 1 h

With sulfuric acid; ammonia; hydrogen; nickel; In diethyl ether; ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00085a001