(R)-tert-butyl 4-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 4-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate
• CAS No.: 1263414-32-9
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Mol file: 1263414-32-9.mol

Synonyms:(R)-tert-butyl 4-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate

Chemical Property of (R)-tert-butyl 4-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 4-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate

There total 2 articles about (R)-tert-butyl 4-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxyphenylboronic acid (5720-07-0) + N-(tert-butoxycarbonyl)pyrrol-2(5H)-one (141293-14-3) → (R)-tert-butyl 4-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate (1263414-32-9)

Guidance literature:

4-methoxyphenylboronic acid; With (3aS,6aS)-3,6-diphenyl-1,3a,4,6a-tetrahydropentalene; chlorobis(ethylene)rhodium(I) dimer; In toluene; at 20 ℃; for 0.25h; Inert atmosphere;

N-(tert-butoxycarbonyl)pyrrol-2(5H)-one; With triethylamine; In water; toluene; at 60 ℃; for 5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol103054a

Reference yield: 85.0%

tert-butyl 2,5-dihydro-4-(4'-methoxyphenyl)-2-oxo-1H-pyrrole-1-carboxylate (928215-95-6) → (R)-tert-butyl 4-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate (1263414-32-9)

Guidance literature:

With bis(norbornadiene)rhodium(l)tetrafluoroborate; zhaophos; hydrogen; In dichloromethane; at 35 ℃; for 48h; under 45603.1 Torr; enantioselective reaction;

DOI:10.1021/acscatal.8b00827

upstream raw materials:

4-methoxyphenylboronic acid

N-(tert-butoxycarbonyl)pyrrol-2(5H)-one

tert-butyl 2,5-dihydro-4-(4'-methoxyphenyl)-2-oxo-1H-pyrrole-1-carboxylate