N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

Base Information

Chemical Name:N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide
CAS No.:1620841-62-4
Molecular Formula:C₃₁H₂₇NO₆
Molecular Weight:509.558
Hs Code.:

Synonyms:N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

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Chemical Property of N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

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Technology Process of N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

There total 4 articles about N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1620841-73-7
N-(6-bromo-4,7-dimethoxy-8-methyl-2-oxo-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

: 536-74-3
phenylacetylene

: 1620841-62-4
N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Schlenk technique;
DOI:10.1016/j.ejmech.2014.06.067

Reference yield:

: 1654766-44-5
C₂₂H₂₀BrNO₆

: 1620841-62-4
N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2014.06.067

Reference yield:

: 31589-45-4
cyclonovobiocic acid

: 1620841-62-4
N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylpyrrolidin-2-one hydrotribromide / acetonitrile / 14 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-methylpyrrolidin-2-one hydrotribromide; potassium carbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; acetonitrile; 3: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2014.06.067