3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate

Base Information

Chemical Name:3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate
CAS No.:1620841-74-8
Molecular Formula:C₃₈H₃₃NO₈S
Molecular Weight:663.748
Hs Code.:

Synonyms:3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate

There total 5 articles about 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1620841-62-4
N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

: 98-59-9
p-toluenesulfonyl chloride

: 1620841-74-8
3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12.0833h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.06.067

Reference yield:

: 1654766-44-5
C₂₂H₂₀BrNO₆

: 1620841-74-8
3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Schlenk technique

3: triethylamine / dichloromethane / 12.08 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2014.06.067

Reference yield:

: 31589-45-4
cyclonovobiocic acid

: 1620841-74-8
3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylpyrrolidin-2-one hydrotribromide / acetonitrile / 14 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Schlenk technique

4: triethylamine / dichloromethane / 12.08 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-methylpyrrolidin-2-one hydrotribromide; potassium carbonate; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2014.06.067