(Z)-tert-butyl 1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamat

Base Information

• Chemical Name: (Z)-tert-butyl 1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamat
• CAS No.: 103421-61-0
• Molecular Formula: C₁₆H₁₅N₃O
• Molecular Weight: 265.315
• Mol file: 103421-61-0.mol

Synonyms:3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Chemical Property of (Z)-tert-butyl 1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamat

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-tert-butyl 1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamat

There total 17 articles about (Z)-tert-butyl 1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-dihydro-1-methyl-5-phenyl-3(R,S)-<(benzyloxycarbonyl)-amino>-2H-1,4-benzodiazepin-2-one (106849-47-2) → 3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (103421-61-0)

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 2h;

Reference yield: 96.0%

3-Azido-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one → 3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (103421-61-0)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran;

DOI:10.1016/S0040-4039(96)01475-X

Reference yield: 95.0%

1,3-dihydro-1-methyl-3-oximino-5-phenyl-2H-1,4-benzodiazepine-2-one → 3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (103421-61-0)

Guidance literature:

nickel; In methanol; ethanol;

upstream raw materials:

1,3-dihydro-1-methyl-5-phenyl-3(R,S)-<(benzyloxycarbonyl)-amino>-2H-1,4-benzodiazepin-2-one

1,3-dihydro-1-methyl-3-oximido-5-phenyl-2H-1,4-benzodiazepin-2-one

C₁₉H₁₈N₄O₃

3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one

Downstream raw materials:

3(R,S)-(3,4,5-trihydroxy-benzoylamino)-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

3(R,S)-(2,5-dihydroxy-benzoylamino)-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

3(R,S)-(3-hydroxy-1-naphthoylamino)-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

[2-(4-Hydroxy-phenyl)-1-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester