1H-1,4-Benzodiazepine-2,3-dione, 1-methyl-5-phenyl-, 3-oxime

Base Information

Chemical Name:1H-1,4-Benzodiazepine-2,3-dione, 1-methyl-5-phenyl-, 3-oxime
CAS No.:103373-62-2
Molecular Formula:C16H13N3O2
Molecular Weight:279.298
Hs Code.:
DSSTox Substance ID:DTXSID30401642
Mol file:103373-62-2.mol

Synonyms:1H-1,4-Benzodiazepine-2,3-dione, 1-methyl-5-phenyl-, 3-oxime;3-hydroxyimino-1-methyl-5-phenyl-1,4-benzodiazepin-2-one;103373-62-2;Oprea1_075751;DTXSID30401642;IWAZSWIKBKIQDB-UHFFFAOYSA-N;1,3-dihydro-1-methyl-3-oximino-5-phenyl-1,4-benzodiazepin-2-one;3-(hydroxyimino)-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Suppliers and Price of 1H-1,4-Benzodiazepine-2,3-dione, 1-methyl-5-phenyl-, 3-oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1H-1,4-Benzodiazepine-2,3-dione, 1-methyl-5-phenyl-, 3-oxime

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:279.100776666
Heavy Atom Count:21
Complexity:466

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=CC=CC=C2C(=NC(=NO)C1=O)C3=CC=CC=C3

Technology Process of 1H-1,4-Benzodiazepine-2,3-dione, 1-methyl-5-phenyl-, 3-oxime

There total 4 articles about 1H-1,4-Benzodiazepine-2,3-dione, 1-methyl-5-phenyl-, 3-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

: 3034-65-9
1-methyl-2,3-dihydro-2-oxo-5-phenyl-1,4-benzodiazepine

: 103373-62-2
1,3-dihydro-1-methyl-3-oximido-5-phenyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: With potassium tert-butylate; isopentyl nitrite; In toluene; at -20 - 0 ℃; for 0.5h;
DOI:10.1021/jo00391a010

Reference yield:

: 14439-71-5
2'-benzoyl-2-bromo-acetanilide

: 103373-62-2
1,3-dihydro-1-methyl-3-oximido-5-phenyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: NH₃ / methanol / 2 h / Heating

2: 93 percent / Aliquat 336, 50percent aq. NaOH / toluene / 4 h / 20 - 25 °C

3: 81.6 percent / t-BuOK, isoamyl nitrite / toluene / 0.5 h / -20 - 0 °C

With sodium hydroxide; potassium tert-butylate; ammonia; Aliquat 336; isopentyl nitrite; In methanol; toluene;
DOI:10.1021/jo00391a010

Reference yield:

: 2835-77-0
(2-aminophenyl)(phenyl)methanone

: 103373-62-2
1,3-dihydro-1-methyl-3-oximido-5-phenyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / CH₂Cl₂; H₂O / 3 h / -10 - 25 °C

2: NH₃ / methanol / 2 h / Heating

3: 93 percent / Aliquat 336, 50percent aq. NaOH / toluene / 4 h / 20 - 25 °C

4: 81.6 percent / t-BuOK, isoamyl nitrite / toluene / 0.5 h / -20 - 0 °C

With sodium hydroxide; potassium tert-butylate; ammonia; Aliquat 336; isopentyl nitrite; In methanol; dichloromethane; water; toluene;
DOI:10.1021/jo00391a010