(4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one

Base Information

Chemical Name:(4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one
CAS No.:177284-10-5
Molecular Formula:C₃₃H₅₄N₂O₅Si₂
Molecular Weight:614.973
Hs Code.:

Synonyms:(4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one

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Technology Process of (4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one

There total 4 articles about (4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 100-39-0
benzyl bromide

: 177283-76-0
(4R,5S,6S,7R)-4,7-dimethyl-5,6-bis((2-(trimethylsilyl)ethoxy)methoxy)-1,3-diazepan-2-one

: 177284-10-5
(4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1021/jm960083n

Reference yield:

: 177283-74-8
dibenzyl ((2R,3S,4S,5R)-3,4-dihydroxyhexane-2,5-diyl)dicarbamate

: 177284-10-5
(4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / N,N-diisopropylethylamine / dimethylformamide / 18 h / Ambient temperature

2: cyclohexene / 20percent Pd(OH)2/C / ethanol / 18 h / Heating

3: CH₂Cl₂ / 18 h / Heating

4: 60 percent / NaH / dimethylformamide / 18 h / Ambient temperature

With sodium hydride; N-ethyl-N,N-diisopropylamine; cyclohexene; palladium dihydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960083n

Reference yield:

: 177283-75-9
dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

: 177284-10-5
(4R,5S,6S,7R)-1,3-Dibenzyl-4,7-dimethyl-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: cyclohexene / 20percent Pd(OH)2/C / ethanol / 18 h / Heating

2: CH₂Cl₂ / 18 h / Heating

3: 60 percent / NaH / dimethylformamide / 18 h / Ambient temperature

With sodium hydride; cyclohexene; palladium dihydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960083n