dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

Base Information

Chemical Name:dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate
CAS No.:177283-75-9
Molecular Formula:C₃₄H₅₆N₂O₈Si₂
Molecular Weight:676.998
Hs Code.:

Synonyms:dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

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Technology Process of dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

There total 6 articles about dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 177283-74-8
dibenzyl ((2R,3S,4S,5R)-3,4-dihydroxyhexane-2,5-diyl)dicarbamate

: 177283-75-9
dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.04.015

Reference yield:

: 105499-10-3,111955-03-4,141884-07-3,82353-55-7
(R)-benzyl-(1-methyl-2-oxoethyl)carbamate

: 177283-75-9
dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: VCl₃(THF)3, Zn-Cu / CH₂Cl₂ / 3 h / Ambient temperature

2: 87 percent / N,N-diisopropylethylamine / dimethylformamide / 18 h / Ambient temperature

With Vanadium (III) chloride-(tris-tetrahydrofuran); copper; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960083n

Reference yield:

: 26607-51-2
N-benzyloxycarbonyl-D-alanine

: 177283-75-9
dibenzyl ((2R,3S,4S,5R)-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.25 h / 0 °C

2: CH₂Cl₂ / 3 h / Ambient temperature

3: LAH / tetrahydrofuran / 1 h / 0 - 25 °C

4: VCl₃(THF)3, Zn-Cu / CH₂Cl₂ / 3 h / Ambient temperature

5: 87 percent / N,N-diisopropylethylamine / dimethylformamide / 18 h / Ambient temperature

With 4-methyl-morpholine; lithium aluminium tetrahydride; Vanadium (III) chloride-(tris-tetrahydrofuran); copper; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960083n